Problems of Drug Therapy Aired at Pharmacology Seminar Here
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• SHREVEPORT JOURNAL Problems of Drug Therapy Aired At Pharmacology Seminar Here Dr. Lester Soyka By EVANGELINE TOLLESON Journal Medical Writer Medical doctors may have to ex-periment for many years before op-timal drug dosages are determined, especially in the case of heart medi-cine, according to Dr. Lester F. Soyka, chairman of the department of pharmacology at Vanderbilt Uni-versity. Soyka was among five guest physi-cians who discussed issues and an-swers on current problems of drug therapy at a pharmacology seminar at LSU Medical Center here Friday. Speaking about digoxin, a medica-tion which for nearly 200 years has helped heart patients to gain stronger heartbeats, Soyka ex-plained that for many years patients have received more medication than they needed during crucial moments of heart failure. These overdoses have often resulted in nausea and other side effects. "The idea used to be you have to use a very large amount in a very short time — to fill the body up (with digoxin) — to get desirable effects," Soyka explained. Using statistical data, he showed that infants and adults do not need to have their bodies "filled up" with the drug, but show improvement with small doses administered repeatedly. With smaller doses, the patient will get the desired effects within a week, but will perhaps avoid many of the side effects, he said. Soyka said the misconception evolved because blood samples taken from persons who have re-ceived the digoxin show a much smaller saturation of the drug than the amount "picked up" by the heart. The doctor said the digoxin content in the heart — where the drug is needed — is 60 to 80 times as much as what is registered in the blood serum. The "smaller dose" theory was first developed in the 1920s, Soyka said, but has only recently become substantiated with statistical data.
|Title||Problems of Drug Therapy Aired at Pharmacology Seminar Here|
Soyka, Lester F.
|Notes||Photo of Dr. Lester Soyka|
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|Source||Louisiana State University Health Sciences Center Shreveport Medical Library (http://lib.sh.lsuhsc.edu)|
|Coverage-Spatial||Shreveport (Caddo, La.)|
|Rights||Physical rights are retained by Louisiana State University Health Sciences Center Shreveport. Copyright is retained in accordance with U.S. copyright laws.|
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